When standard treatments have not worked, advanced options offer hope.
Overview
Treatment-Resistant Depression (TRD) refers to major depressive disorder that has not responded adequately to at least two adequate trials of antidepressant medication. It affects a significant number of people with depression and can feel discouraging — but it is not a dead end. Advanced, evidence-based interventional treatments such as TMS, Ketamine, and Spravato offer new pathways to relief for patients who have not found success with standard approaches.
How We Treat It
Frequently Asked Questions
Depression is considered treatment-resistant when symptoms have not improved after at least two adequate antidepressant trials (proper dose and duration). A thorough re-evaluation can also uncover factors like misdiagnosis or co-occurring conditions.
TMS uses targeted magnetic pulses to stimulate underactive brain regions involved in mood regulation. It is FDA-cleared specifically for treatment-resistant depression and is non-invasive with minimal side effects.
Unlike traditional antidepressants that take weeks, Ketamine can produce noticeable improvement within hours to days — making it a valuable option for severe, treatment-resistant cases.
If you or a loved one are experiencing symptoms of treatment-resistant depression, our team is here to help. Schedule a confidential evaluation today.